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Neospiramycin I is a macrolide antibiotic and derivative of spiramycin I.1 It is active against the macrolide-sensitive KB210, but not the macrolide-resistant KB224, strain of S. aureus (MICs = 3.12 and >100 µg/ml, respectively), as well as B. cereus, B. subtilis, M. luteus, E. coli, and K. pneumoniae (MICs = 1.56, 3.12, 3.12, 0.2, 50, and 12.5 µg/ml, respectively). Neospiramycin I binds to E. coli ribosomes with an IC50 value of 1.2 µM. It protects against mortality in a mouse model of S. pneumoniae type III infection (ED50 = 399.8 mg/kg).2

1.Sano, H., Inoue, M., and  mura, S.Chemical modification of spiramycins. II. Synthesis and antimicrobial activity of 4’-deoxy derivatives of neospiramycin I and their 12-(Z)-isomersJ. Antibiot. (Tokyo)37(7)738-749(1984) 2.Sano, H., Inoue, M., Yamashita, K., et al.Chemical modification of spiramycins. I. Synthesis of the acetal derivatives of neospiramycin IJ. Antibiot. (Tokyo)36(10)1336-1344(1983)

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