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Cefsulodin is a β-lactam antibiotic that lyses actively-growing E. coli by binding specifically to the intermembrane proteins, penicillin-binding proteins 1a and b, whose transglycosylase and transpeptidase activities are involved in cell elongation and septation.1 Cefsulodin has been used in combination with other β-lactam antibiotics, such as cefazolin as a strategy to circumvent drug resistance.2

1.Jacoby, G.H., and Young, K.D.Cell cycle-independent lysis of Escherichia coli by cefsulodin, an inhibitor of penicillin-binding proteins 1a and 1bJournal of Bacteriology173(1)1-5(1991) 2.Sarkar, S.K., Dutta, M., Kumar, A., et al.Sub-inhibitory cefsulodin sensitization of E. coli to  -lactams is mediated by PBP1b inhibitionPLoS One7(11)(2012)

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