MMV008138CS-01Y72468_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	10mM*1mL in DMSO 5mg 10mg 50mg 100mg
CAS	1679333-73-3
别名	N/A
化学名	N/A
分子式	C18H14Cl2N2O2
分子量	361.22
溶解度	DMSO: 125 mg/mL (346.05 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

描述：

MMV008138 is a species-selective antimalarial agent which targets the enzyme 2- C-methyl-d-erythritol 4-phosphate cytidylyltransferase (IspD) in the MEP pathway, with an IC50 of 250 nM for P. falciparum Dd2 strain[1][2]. IC50: 250 nM (P. falciparum Dd2 strain)[1]

[1]. Ghavami M, et al. Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3 S)-MMV008138 and Analogs. ACS Infect Dis. 2018 Apr 13;4(4):549-559. [2]. Yao ZK, et al. Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1515-9.

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标签：MMV008138

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