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Cefoperazone is a cephalosporin antibiotic which inhibits rMrp2-mediated [3H]E217βG uptake with an IC50 of 199 μM [1].

The inhibition profile for cefoperazone was biphasic with IC50, high and IC50, low values of 6.66 ± 3.23 μM and 3.88 ± 1.32 mM, respectively, indicating that cefoperazone may inhibit two binding sites that mediated [3H]E217βG transport [1]. Cefoperazone is a sterile, broad-spectrum, semisynthetic, parenteral cephalosporin antibiotic for intravenous or intramuscular administration. After intravenous administration of 2 g cefoperazone, levels in serum ranged from 202 μg/mL to 375 μg/mL depending on the period of drug administration. After intramuscular injection of 2 g of cefoperazone, the mean peak serum level was111 μg/mL at 1.5 hours. At 12 hours after dosing, mean serum levels were still 2 to 4 μg/mL.Cefoperazone is 90% bound to serum proteins.The apparent volume of distribution was 10 to 13L. The half-life of the drug varied from 1.6 to 2.4 hours, and the serum clearance was between 75 and 96 ml/min [2].

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