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Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].

In vitro: In cultured MG-63 human osteosarcoma cell line, cefazolin (100 μg/ml) showed little or no effect on osteoblast replication. Cefazolin (200μg/ml) significantly decreased cell replication, and 10,000 μg/ml caused cell death [2].

In vivo: In patients with normal and various degrees of compromised renal function, administration of cefazolin significantly decreased the urinary concentration and percentage of the dose excreted in the urine [3]. The half-life of cefazolin in serum of normal persons was 1.9 hr and as long as 35 hr in severely uremic patients. In uremic patients, cefazolin was well tolerated [4].

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