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Ergosterol peroxide is an oxidized sterol and derivative of ergosterol that has been found in S. aspratus and has diverse biological activities.1,2,3,4,5 It is active against the P. falciparum chloroquine-sensitive strain FCA 20/GHA with an IC50 value of 8.2 µM.2 Ergosterol peroxide (6.25-50 µM) induces apoptosis in LNCaP and DU145 prostate cancer cells.3 It inhibits growth of SNU-1 gastric, SNU-354 hepatoma, and SNU-C4 colorectal cancer cells (IC50s = 18.7, 158.2, and 84.6 µM, respectively).6 Ergosterol peroxide (60 µM) inhibits LPS-induced NF-kB DNA-binding activity and production of TNF-α in RAW 264.7 cells.4 Topical application of ergosterol peroxide reduces ear edema in a mouse model of inflammation induced by phorbol 12-myristate 13-acetate with an ID50 value of 0.2 mg/ear.5

1.Nielson, J.R., Fredrickson, E.K., Waller, T.C., et al.Sterol oxidation mediates stress-responsive Vms1 translocation to mitochondriaMol. Cell68(4)673-685(2017) 2.Kuria, K.A.M., Chepkwony, H., Govaerts, C., et al.The antiplasmodial activity of isolates from Ajuga remotaJ. Nat. Prod.65(5)789-793(2002) 3.Russo, A., Cardile, V., Piovano, M., et al.Pro-apoptotic activity of ergosterol peroxide and (22E)-ergosta-7,22-dien-5α-hydroxy-3,6-dione in human prostate cancer cellsChem. Biol. Interact.184(3)352-358(2010) 4.Kobori, M., Yoshida, M., Ohnishi-Kameyama, M., et al.Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cellsBr. J. Pharmacol.150(2)209-219(2007) 5.Yasukawa, K., Aoki, T., Takido, M., et al.Inhibitory effects of ergosterol isolated from the edible mushroom Hypsizigus marmoreus on TPA‐induced inflammatory ear oedema and tumour promotion in micePhytother. Res.8(1)10-13(1994) 6.Nam, K.S., Jo, Y.S., Kim, Y.H., et al.Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipesLife Sci.69(2)229-237(2001)

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