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Ceratotoxin A, a 29-residue peptide isolated from the accessory gland secretion fluid, with strong anti-bacterial activity.

Ceratotoxin A is a 29-residue peptide isolated from the accessory gland secretion fluid, shows anti-E.coli activity, and is heat stable[1]. Ceratotoxin A is effective against Escherichia coli ATCC 23739, Pseudomonas aeruginos ATCC 27853, and Bacillus subtilis ATCC 6633 with minimal inhibitory concentration (MIC) of 7, 7, and 3.5 μM[2].

[1]. Marchini D, et al. Purification and primary structure of ceratotoxin A and B, two antibacterial peptides from the female reproductive accessory glands of the medfly Ceratitis capitata (Insecta:Diptera). Insect Biochem Mol Biol. 1993 Jul;23(5):591-8. [2]. Marri L, et al. The novel antibacterial peptide ceratotoxin A alters permeability of the inner and outer membrane of Escherichia coli K-12. Curr Microbiol. 1996 Jul;33(1):40-3.

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