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Cefotetan is a cephamycin antibiotic that is active against both Gram-positive and Gram-negative bacteria including isolates of E. coli, S. aureus, K. pneumoniae, and P. maltophilia (MICs = 0.03-32 mg/ml). It reduces mortality by 50% in a rabbit model of fecal peritonitis when administered at a dose of 25 mg/kg twice daily. Formulations containing cefotetan have been used in the treatment of various bacterial infections.

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