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Betulin 3,28-diacetate is a triterpene and derivative of betulin that has been found in B. pendula and has antiviral and hepatoprotective activities.1,2,3 It inhibits Semliki Forest virus (SFV) replication in virus-infected Huh7 cells (IC50 = 9.1 µM).2 Betulin 3,28-diacetate (20 mg/kg) increases the rate of bile secretion, a marker of hepatic function, in rat models of hepatitis induced by carbon tetrachloride, ethanol, or tetracycline .3

1.Salah, A., and Bakibaev, A.Effective method of extraction of betulin diacetate from birch barkJ. Nat. Prod. Resour.3(1)90-93(2017) 2.Pohjala, L., Alakurtti, S., Ahola, T., et al.Betulin-derived compounds as inhibitors of alphavirus replicationJ. Nat. Prod.72(11)1917-1926(2009) 3.Flekhter, O.B., Karachurina, L.T., Poroikov, V.V., et al.The synthesis and hepatoprotective activity of esters of the lupane group triterpenoidsRuss. J. Bioorg. Chem.26(3)192-200(2000)

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