ActagardinCS-01Y71411_上海莼试生物技术有限公司

产品详情

一、概述：

化学性质：

规格	1mg 5mg
CAS	59165-34-3
别名	Antibiotic A 3802-IV-3,Gardimycin
化学名	D-cysteinyl-L-serylglycyl-L-tryptophyl-L-valyl-L-cysteinyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-leucyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-isoleucyl-L-a-glutamyl-L-cysteinylglycyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-valyl-L-isoleucyl-L-cysteinyl-L-alany
分子式	C81H124N20O24S4
分子量	1890.2
溶解度	Soluble in ethanol;methanol;DMSO;dimethyl formamide
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Actagardin is a tetracyclic antibiotic.

Actagardin is a tetracyclic antibiotic produced by several species of Actinoplanes.

In vitro: During the repeated fermentations of actagardin, two new compounds, named D and E, were isolated. Compound D was found to be twice as active as actagardin against Streptococcus pyogenes C 203 and four times more active than actagardin against Staphylococcus aureus ATCC 6538, S. pneumoniae UC 41, and S. aureus TOUR in the in-vitro tests [1].

In vivo: Animal study showed that compound D was also more effective than the parent compound actagardin against experimental infections in mice with either S. pyogenes C 203 or S. aureus TOUR, after sc administration. However, compound D was ineffective at doses up to 150 mg/kg when given orally to mice infected with S. pyogenes C 203. Moreover, compound D (LD50 1,250 mg/kg, mice, ip) was about 2.5 times more toxic than actagardine (3,310 mg/kg). In addition, compound E showed practically no in vitro activity up to 50 μg/ml against the tested organisms [1].

Clinical trial: So far, no clinical study has been conducted.

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：Actagardin

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产品详情

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