化学性质:
规格 | 10mM (in 1mL DMSO)5mg10mg50mg500mg1g |
CAS | 1219168-18-9 |
别名 | BML-275 2HCl,Compound C 2HCl |
化学名 | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;dihydrochloride |
分子式 | C24H25N5O.2HCl |
分子量 | 472.41 |
溶解度 | ≥ 5.9mg/mL in DMSO, <6.74 mg/mL in H2O, ≥ 11.34 mg/mL in 0.9% NS |
储存条件 | Store at -20° C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
IC50: Dorsomorphin inhibited BMP4-induced phosphorylation of BMP-responsive SMADs in a dose-dependent manner (half maximal inhibitory concentration (IC50) =0.47 mM).
Bone morphogenetic protein (BMP) signals coordinate developmental patterning and have essential physiological roles in mature organisms. The first known small-molecule inhibitor of BMP signaling, dorsomorphin, were identified in a screen for compounds that perturb dorsoventral axis formation in zebrafish.
In vitro: Previoius researchers found that dorsomorphin selectively inhibits the BMP type I receptors ALK2/ALK3/ALK6 leading to block BMP-mediated SMAD
In vivo: The systemic challenge with iron rapidly induced SMAD
Clinical trial: Dorsomorphin is still in preclinical development stage and no clinicl trial is ongoing currently.
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标签:Dorsomorphin 2HCl
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