化学性质:
规格 | 1mg 5mg 10mg 25mg |
CAS | 902779-59-3 |
别名 | Akt Inhibitor XI |
化学名 | copper(II) (Z)-2-((4-oxo-4H-chromen-3-yl)methylene)hydrazinecarbimidothioate chloride hydrochloride |
分子式 | C11H9Cl2CuN3O2S |
分子量 | 381.73 |
溶解度 | DMSO: 0.1 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
The kinase Akt (also known as protein kinase B or PKB) modulates cell proliferation, metabolism, and survival, as well as angiogenesis.[1],[2] Akt inhibitor XI is a cell-permeable, copper-containing 3-formylchromone derivative that inhibits Akt in an array of cancer cells (IC50s = 10-34 μM).[3] It also causes NF-κB inactivation in an orthotopic pancreatic tumor model using COLO 357 cells.3 Molecular modeling indicates that this inhibitor interacts with the pleckstrin homology and kinase domains of Akt. Akt inhibitor XI is commonly used in the range of 1-20 μM to assess the role of Akt in cellular responses.[4],[5],[6]
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