PIK-108CS-01Y71227_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	10mM*1 mL in DMSO 5 mg 10 mg 25 mg 50 mg 100 mg
CAS	901398-68-3
别名	N/A
化学名	N/A
分子式	C22H24N2O3
分子量	364.44
溶解度	DMSO : 50 mg/mL (137.20 mM; Need ultrasonic)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

PIK-108 is a non-ATP competitive, allosteric p110β/p110δ selective inhibitor[1].

PIK-108 (0.1-10 μM; 1 hour) blocks phosphorylation of PKB/Akt[1].

[1]. Zachary A Knight, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47.

[2]. Jack S Chen, et al. Characterization of structurally distinct, isoform-selective phosphoinositide 3’-kinase inhibitors in combination with radiation in the treatment of glioblastoma. Mol Cancer Ther. 2008 Apr;7(4):841-50.

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：PIK-108

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抑制剂 > p13k/Akt/mTOR 信号传导 > PIK-108

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