上海莼试生物技术有限公司
上海莼试生物技术有限公司
化学性质：
| 规格 | 10mM (in 1mL DMSO) 2mg 5mg 10mg 50mg 100mg |
| CAS | 2070015-29-9 |
| 别名 | N/A |
| 化学名 | 2-(pyridin-3-yl)naphtho[2,3-d]oxazole-4,9-dione |
| 分子式 | C16H8N2O3 |
| 分子量 | 276.25 |
| 溶解度 | ≥ 10.85mg/mL in DMSO with gentle warming |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述：
SJB3-019A is a potent and novel inhibitor of USP1 with IC50 value of 0.0781 μM [1].
Ubiquitin-specific protease 1 (USP1) is a deubiquitinating (DUB) enzyme and removes polyubiquitin chains from the DNA binding 1 (ID1) protein, which plays an important role in the proliferation and progression of cancers, such as leukemia [1].
SJB3-019A is a potent and novel USP1 inhibitor. In K562 cells, SJB3-019A exhibited 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity. In HeLa cells, SJB3-019A increased the levels of Ub-PCNA and Ub-FANCD2 and reduced the homologous recombination activity [1].
特别提醒：
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
标签：SJB3-019A
联系人：高小姐
手 机：13585831301
Q Q：3004967995
座 机：021-59541103
传 真：021-60443211
地 址：上海嘉定区嘉罗公路1661
