TWS119CS-01Y71143_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	10mM (in 1mL DMSO) 10mg 20mg 50mg 100mg
CAS	601514-19-6
别名	N/A
化学名	3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
分子式	C18H14N4O2
分子量	318.33
溶解度	0.3mg/mL in ethanol, 20mg/mL in DMSO & DMF
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

TWS119 is an inhibitor of glycogen synthase kinase-3β (GSK-3β) with IC50 value of 30nM [1].

TWS119 is screened out from a library of pyrrolopyrimidines as a molecule that selectively induces neuronal differentiation when using mouse P19 EC cells. TWS119 binds to GSK-3β tightly with a Kd value of 126nM and shows an inhibition with IC50 value of 30nM. The combination of TWS119 and GSK-3β modulates the activity of the complex and triggers downstream transcriptional events lead the neuronal induction. Besides that, TWS119 promotes neuronal differentiation of mESCs through another mechanism but not the canonical Wnt signaling pathway [1, 2].

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标签：TWS119

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抑制剂 > p13k/Akt/mTOR 信号传导 > TWS119

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