TAS-103 dihydrochloride (BMS-247615 dihydrochloride)CS-01Y70946

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一、概述：

化学性质：

规格	5mg 10mM*1mLinWater 50mg 100mg
CAS	174634-09-4
别名	N/A
化学名	N/A
分子式	C20H21Cl2N3O2
分子量	406.31
溶解度	H2O : 15.3 mg/mL (37.66 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

TAS-103 dihydrochloride is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.

TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells[1]. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103[2]. TAS-103 inhibits the viability of HeLa cells, with an IC50 of 40 nM. TAS-103 (10 μM) disrupts signal recognition particle (SRP) complex formation, and induces destabilization of SRP14 and SRP19 and its eventual degradation[3].

TAS-103 (30 mg/kg, i.v.) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103[2].

特别提醒：

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标签：TAS-103 dihydrochloride (BMS-247615 dihydrochloride)

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抑制剂 > p13k/Akt/mTOR 信号传导 > TAS-103 dihydrochloride (BMS-247615 dihydrochloride)

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