PD 407824CS-01Y70740_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	1mg 5mg 10mg
CAS	622864-54-4
别名	N/A
化学名	9-hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
分子式	C20H12N2O3
分子量	328.3
溶解度	DMSO: 18 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

PD 407824 is an inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s = 47 and 97 nM, respectively). It is selective for Chk1 and WEE1 over PKC (IC50 = 3.4 uM), Cdk4 (IC50 = 3.75 uM), as well as c-Src and the PDGF and FGF receptors (IC50s = >50 uM for all), and other Cdks (IC50s = >50 uM). PD 407824 sensitizes SK-OV-3 and OVCAR-3 ovarian cancer cells, as well as cisplatin-resistant A2780cis cells, to cisplatin when used at a concentration of 0.5 uM. It also sensitizes C2C12 myoblasts to bone morphogenic protein 4 (BMP4) and, when used in combination with BMP4, inhibits myotube formation and induces myoblasts to differentiate into mature osteoblasts. PD 407824, in combination with BMP4, induces human embryonic stem cells to differentiate into cells with mesoderm or cytotrophoblast stem cell lineages.

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

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标签：PD 407824

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抑制剂 > p13k/Akt/mTOR 信号传导 > PD 407824

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