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Adenylosuccinic acid is a purine nucleotide and an intermediate in the purine nucleotide cycle.1 It is converted into AMP and fumarate by adenylosuccinate lyase in the cytosol. Adenylosuccinic acid (10 μM) inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay.2 Adenylosuccinic acid (10 μM) increases glucose-induced insulin exocytosis in 832/13 INS-1 pancreatic β-cells.3 It induces contractions in isolated guinea pig uterus strips when used at a concentration of 100 μM.4

1.Waarde, A.Operation of the purine nucleotide cycle in animal tissuesBiol. Rev. Camb. Philos. Soc.63(2)259-298(1988) 2.Halonen, J., and Nedergaard, J.Adenosine 5’-monophosphate is a selective inhibitor of the brown adipocyte nonselective cation channelJ. Membr. Biol.188(1)183-197(2002) 3.Gooding, J.R., Jensen, M.W., Dai, X., et al.Adenylosuccinate is an insulin secretagogue derived from glucose-induced purine metabolismCell Rep.13(1)157-167(2015) 4.Nishida, Y., and Miyamoto, T.Contractile effect of succinylpurines on guinea pig uterusGen. Pharmacol.19(2)277-279(1988).

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