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5-Heneicosylresorcinol is an alkylresorcinol that has been found in wheat, rye, triticale, and barley.1 It reduces hydrogen peroxide-induced DNA damage in HT-29 cells when used at a concentration of 100 μmol/L.2 5-Heneicosylresorcinol (160 μg/ml), when used in combination with 5-nonadecanoylresorcinol, inhibits migration and invasion, reduces the number of LC3 puncta, a marker of autophagy, and decreases survival in HepG2 cells.3

|1. Ross, A.B., Shepherd, M.J., Schüpphaus, M., et al. Alkylresorcinols in cereals and cereal products. J. Agric. Food Chem. 51(14), 4111-4118 (2003).|2. Parikka, K., Rowland, I.R., Welch, R.W., et al. In vitro antioxidant activity and antigenotoxicity of 5-n-alkylresorcinols. J. Agric. Food Chem. 54(5), 1646-1650 (2006).|3. Guo, Y.-Z., Yang, X.-M., and Li, Y.-Y. Effect of alkylresorcinols on autophagy, migration, and invasion of HepG2 cells. J. Food Sci. 84(10), 3063-3068 (2019).

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