DUBs-IN-1CS-01Y70622_上海莼试生物技术有限公司

产品详情

一、概述：

化学性质：

规格	10mM*1mL in DMSO 5mg 10mg 50mg 100mg 200mg 500mg
CAS	924296-18-4
别名	N/A
化学名	N/A
分子式	C20H11N5O
分子量	337.33
溶解度	DMSO: 100 mg/mL (296.45 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

DUBs-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.24 μM for USP8. IC50: 0.24 μM (USP8)[1]

DUBs-IN-1 (22 f) is an active inhibitor of ubiquitin-specific proteases, with an IC50 of 0.24 μM for USP8. DUBs-IN-1 is inactive toward USP7 (IC50, >100 μM). DUBs-IN-1 and its analogs reduce the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50s ranging from 0.5 μM to 1.5 μM[1].

[1]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：DUBs-IN-1

热卖产品最新促销最新推荐

抑制剂 > DNA损伤/DNA修复 > DUBs-IN-1

产品简介

产品详情

一、概述：

联系我们