化学性质:
规格 | 10mM (in 1mL DMSO) 10mg 50mg 100mg 500mg |
CAS | 154-93-8 |
别名 | N/A |
化学名 | (Z)-N,N'-bis(2-chloroethyl)-N-nitrosocarbamimidic acid |
分子式 | C5H9Cl2N3O2 |
分子量 | 214.05 |
溶解度 | DMSO: 100 mM,Ethanol: 100 mM,Water: 25 mM |
储存条件 | -20°C, protect from light |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.
Carmustine is an antitumor chemotherapeutic agent. Carmustine (8, 80, and 800 μM) decreases N-acetyltransferase (NAT) activities for 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) in rat glial tumor cytosol and intact cells. In rat glial tumor cells, the DNA-AF adduct increases, and carmustine decreases the formation of DNA-AF adduct[1].
Carmustine (BCNU; 25 mg/kg, i.p.) causes higher levels of the rhe ratio of liver weight to body weight and plasma conjugated bilirubin, and lower biliary flow, oxidised glutation levels (GSSG) and reduced glutation (GSH)/GSSG values compared with control rats[2].
特别提醒:
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2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
标签:Carmustine
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