Adenosine 3’-monophosphate (sodium salt hydrate)CS-01Y70406

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化学性质：

规格	50 mg 100 mg 250 mg
CAS	N/A
别名	N/A
化学名	N/A
分子式	C10H14N5O7P·XNa [XH2O]
分子量	347.2
溶解度	PBS (pH 7.2): 10 mg/ml
储存条件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Adenosine 3’-monophosphate is a nucleotide and metabolite formed via hydrolysis of 2’,3’-cAMP by metal-dependent phosphodiesterases.1 It reduces proliferation of rat preglomerular vascular smooth muscles cells (PGVSMCs) and glomerular mesangial cells (GMCs) in a concentration-dependent manner, an effect that is abolished by the adenosine A2B receptor antagonist MRS1754.2 Adenosine 3’-monophosphate is also a metabolic intermediate in the biosynthesis of adenosine .

1.Rao, F., Yaning, Q., Murugan, E., et al.20,30-cAMP hydrolysis bymetal-dependent phosphodiesterases containing DHH, EAL, and HD domains is non-specific: Implications for PDE screeningBiochem. Bioph. Res. Commun.398(3)500-505(2010) 2.Jackson, E.K., Gillespie, D.G., and Dubey, R.K.2’-AMP and 3’-AMP inhibit proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptorsJ. Pharmacol. Exp. Ther.337(2)444-450(2011)

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抑制剂 > DNA损伤/DNA修复 > Adenosine 3’-monophosphate (sodium salt hydrate)

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