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Leflunomide is an agonist of aryl hydrocarbon receptor (AHR) [1]. As an immunoregulatory agent, Leflunomide can be administrated orally. A771726 (teriflunomide) is an active drug formed non-enzymatically from leflunomide [2].

Leflunomide has been demonstrated to expand Tregs levels in peripheral blood and stem cells subsets as well as to increase the migration of these cells into the injured kidney.  Leflunomide has been displayed to increase cells expressed IL-10 and reduce cells expressed IL-17- and IL-23 in ischemic-reperfused kidney [1].

Leflunomide has shown to significantly lower the lipid peroxidation in male Wistar albino rats of sepsis. Meanwhile, leflunomide successfully inhibited the protein carbonyl rise and NO rise in bowel [2]. Leflunomide has shown to reduce cell proliferation, inhibit tumor marker expression, as well as down-regulate neuroendocrine marker ASCL1 protein expression in a dose- and time-dependent manner in human MTC-TT cells [3].

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