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hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 µM). hSMG-1 inhibitor 11j can be used for the research of cancer[1].

hSMG-1 inhibitor 11j (0.3-3 µM; 6 h) significantly reduces UPF1 phosphorylation at 0.3 µM, and eliminates it at 1 µM in MDA 361 cells[1].hSMG-1 inhibitor 11j inhibits MDA468 cell proliferation, with an IC50 of 75 nM[1].

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