上海莼试生物技术有限公司
上海莼试生物技术有限公司
化学性质：
| 规格 | 250mg 500mg |
| CAS | 244021-67-8 |
| 别名 | N/A |
| 化学名 | N/A |
| 分子式 | C16H10N2O5S |
| 分子量 | 342.33 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述：
Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively[1]. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β[2]. Cdk1/cyclin B|55 nM (IC50)|cdk2/cyclin A|35 nM (IC50)|CDK2/cyclinE|150 nM (IC50)|Cdk4/cyclin D1|300 nM (IC50)|CDK5/p35|65 nM (IC50)|GSK-3β
[1]. Hoessel R, et al. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol. 1999 May;1(1):60-7. [2]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors• J Biol Chem. 2001 Jan 5;276(1):251-60.
特别提醒：
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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