2′-Deoxy-2′-fluoroadenosineCS-01Y70255_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	100 mg
CAS	64183-27-3
别名	N/A
化学名	N/A
分子式	C10H12FN5O3
分子量	269.23
溶解度	N/A
储存条件	4°C, stored under nitrogen
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP[1].

[1]. A E Hassan, et al. A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy. Nucleosides Nucleotides Nucleic Acids. 2000 Mar;19(3):559-65

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标签：2′-Deoxy-2′-fluoroadenosine

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抑制剂 > DNA损伤/DNA修复 > 2′-Deoxy-2′-fluoroadenosine

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