UNC2541CS-01Y70226_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	5mg 10mg 25mg 50mg 100mg 200mg
CAS	1612782-86-1
别名	N/A
化学名	N/A
分子式	C24H34FN7O2
分子量	471.57
溶解度	DMSO: 10 mg/mL (21.21 mM; ultrasonic and warming and heat to 60°C)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM)[1]. UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl (IC50, 120 nM), Tyro3 (IC50, 220 nM) and Flt3 (IC50, 320 nM). UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM)[1].

[1]. McIver AL, et al. Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors. ChemMedChem. 2017 Feb 3;12(3):207-213.

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1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

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标签：UNC2541

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