PF-4618433CS-01Y70163_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	10mM*1 mL in DMSO 5 mg 10 mg 25 mg 50 mg
CAS	1166393-85-6
别名	N/A
化学名	N/A
分子式	C24H27N7O2
分子量	445.52
溶解度	DMSO : 125 mg/mL (280.57 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration[1][2].

PF-4618433 (0.1-1.0 μM; 7 days) promotes osteogenesis of hMSC cultures. PF-4618433 increases in both alkaline phosphatase (ALP) activity and mineralization in a dependent manner[1].PF-4618433 (0.1-0.3 μM; 24 hours) enhances osteoblast proliferation[2].PF-4618433 (0.0125-0.3 μM; 14 or 21 days) enhances calcium deposition at the concentrations of 0.1 and 0.3 μM[2].

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：PF-4618433

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抑制剂 > 酪氨酸激酶 > PF-4618433

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