Tyrosine kinase-IN-1CS-01Y70116_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	10mM*1mLinDMSO 1mg 5mg 10mg
CAS	705946-27-6
别名	N/A
化学名	N/A
分子式	C26H28FN5O
分子量	445.53
溶解度	DMSO : ≥ 62.5 mg/mL (140.28 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively.

Tyrosine kinase-IN-1 is from reference (compound 8K)[1].

Tyrosine kinase-IN-1 shows a reasonable PK profile (AUC(0-∞)=1.9, t1/2=4.6 h). It has a favorable oral bioavailability (F=63%) in rats[1].

[1]. Moon K, et al. The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 22 (2012) 4979-4985

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标签：Tyrosine kinase-IN-1

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