Mutated EGFR-IN-2CS-01Y69961_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	100mg 250mg 500mg
CAS	2050906-97-1
别名	N/A
化学名	N/A
分子式	C29H35FN8O3
分子量	562.64
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=<1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity[1]. EGFRT790M EGFRL858R EGFRex19del EGFR (L858R/T790M)|<1 nM (IC50)|EGFR (ex19del/T790M)

[1]. 2, 4-di-(nitrogen containing group) substituted pyrimidine compound and preparation method and use thereof.

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：Mutated EGFR-IN-2

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抑制剂 > 酪氨酸激酶 > Mutated EGFR-IN-2

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