化学性质:
规格 | 1mg 5mg |
CAS | 269390-69-4 |
别名 | N/A |
化学名 | N-(4-chlorophenyl)-2-[(4-pyridinylmethyl)amino]-benzamide |
分子式 | C19H16ClN3O |
分子量 | 337.8 |
溶解度 | ≤25mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
VEGFR tyrosine kinase inhibitor II is a pyridinyl-anthranilamide compound that inhibits the kinase activities of VEGFR2 (KDR), VEGFR1 (FLT1), and c-Kit (IC50s = 20, 180, and 240 nM, respectively).1 It displays minimal activity against c-Src and EGFR (IC50s = 7 and 7.3 µM, respectively) and is inactive against Cdk1, c-Met, IGF-1R, and PKA (IC50s > 10 µM).1 VEGFR tyrosine kinase inhibitor II has been investigated for its potential to inhibit tumor induced angiogenesis.[1]
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