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2-Phospho-L-ascorbic acid trisodium salt acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production. Human Endogenous Metabolite

2-Phospho-L-ascorbic acid (Asc 2-P) acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production. 2-Phospho-L-ascorbic acid is a stable derivative of L-ascorbic acid (AA) and possesses similar biological properties as AA. AA and Asc-2P regulate a number of biological processes[1]. When 2-Phospho-L-ascorbic acid is added together with DHT, DHT-induced DKK-1 mRNA expression in DPCs is significantly attenuated. It is also found that DKK-1 promoter activity is increased by DHT treatmen. When 2-Phospho-L-ascorbic acid is added together with DHT, DHT-induced activation of luciferase activity is significantly repressed[2].

[1]. Bae SH, et al. L-ascorbic acid 2-phosphate and fibroblast growth factor-2 treatment maintains differentiation potential in bone marrow-derived mesenchymal stem cells through expression of hepatocyte growth factor. Growth Factors. 2015 Apr;33(2):71-8. [2]. Kwack MH, et al. L-ascorbic acid 2-phosphate represses the dihydrotestosterone-induced dickkopf-1 expression in human balding dermal papilla cells. Exp Dermatol. 2010 Dec;19(12):1110-2.

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