CA-4948CS-01Y69807_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	10mM*1mLinDMSO 5mg 10mg 25mg 50mg 100mg
CAS	1801343-74-7
别名	N/A
化学名	N/A
分子式	C21H19N7O3
分子量	417.42
溶解度	DMSO : 13.89 mg/mL (33.28 mM);H2O : < 0.1 mg/mL (insoluble)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

CA-4948 is a selective and potent IRAK4 inhibitor.

CA-4948 is a selective and potent IRAK4 inhibitor which can be used as a therapeutic agent for hematological cancers with dysregulated TLR/MYD88/IRAK4 signaling. CA-4948 exhibits favorable DMPK properties, oral bioavailability, and is well tolerated in mice. Furthermore, CA-4948 is previously shown to exhibit dose-dependent efficacy in ABC-DLBCL MYD88-L265P xenograft tumor models[1].

[1]. Robert N. Booher, et al. Abstract 1168: Efficacy of the IRAK4 inhibitor CA-4948 in patient-derived xenograft models of diffuse large B cell lymphoma. AACR Annual Meeting 2017; April 1-5, 2017;

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2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：CA-4948

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抑制剂 > 酪氨酸激酶 > CA-4948

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