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抑制剂 > 酪氨酸激酶 > CGP 77675 (hydrate)
产品名称:
CGP 77675 (hydrate)
型号:
CS-01Y69724
生产地址
进口、国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

1 mg 5 mg 10 mg 25 mg

CAS

N/A

别名

N/A

化学名

N/A

分子式

C26H29N5O2•XH2O

分子量

443.5

溶解度

DMSO: 10 mg/ml

储存条件

-20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                            

CGP 77675 is an inhibitor of Src family kinases (SFKs) that blocks the phosphorylation of peptide substrates and autophosphorylation of purified c-Src (IC50s = 5-20 and 40 nM, respectively).1 It also inhibits the SFKs Lck and c-Yes with low nanomolar IC50 values.1,2,3 CGP 77675 is used to elucidate the role of SFKs in such processes as bone resorption, tight junction formation in epithelial cells, and allograft survival.2,1,4 It can also be used in combination with the GSK3 inhibitor CHIR99021 to maintain mouse embryonic stem cells.5

1.Missbach, M., Jeschke, M., Feyen, J., et al.A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivoBone24(5)437-449(1999) 2.Chen, Y.-H., Goodenough, D.A., and Jeansonne, B.Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cellsMol. Biol. Cell13(4)1227-1237(2002) 3.?u?a, M., Luong-Nguyen, N.-H., Crespo, J., et al.Active recombinant human tyrosine kinase c-Yes: expression in baculovirus system, purification, comparison to c-Src, and inhibition by a c-Src inhibitorProtein Expr. Purif.19(1)99-106(2000) 4.Zhang, Q., Fairchild, R.L., Reich, M.B., et al.Inhibition of Src kinases combined with CD40 ligand blockade prolongs murine cardiac allograft survivalTransplantation80(8)1112-1120(2005) 5.Shimizu, T., Ueda, J., Ho, J.C., et al.Dual inhibition of Src and GSK3 maintains mouse embryonic stem cells, whose differentiation is mechanically regulated by Src signalingStem Cells30(7)1394-1404(2012)

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:CGP 77675 (hydrate) 

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