化学性质:
规格 | 1mg 5mg 10mg 25mg |
CAS | 234772-64-6 |
别名 | N/A |
化学名 | 1-[2-[4-[4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]ethyl]-4-piperidinol |
分子式 | C26H29N5O2 |
分子量 | 443.5 |
溶解度 | DMSO: 10 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
CGP 77675 is an inhibitor of Src family kinases (SFKs) that blocks the phosphorylation of peptide substrates and autophosphorylation of purified c-Src (IC50s = 5-20 and 40 nM, respectively). It also inhibits the SFKs Lck and c-Yes with low nanomolar IC50 values. CGP 77675 is used to elucidate the role of SFKs in such processes as bone resorption, tight junction formation in epithelial cells, and allograft survival. It can also be used in combination with the GSK3 inhibitor CHIR99021 to maintain mouse embryonic stem cells.
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