上海莼试生物技术有限公司
上海莼试生物技术有限公司
化学性质：
| 规格 | 1mg 5mg 10mg |
| CAS | 1346601-52-2 |
| 别名 |
|
| 化学名 | N-(3-ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine |
| 分子式 | C23H25N3O4 |
| 分子量 | 407.5 |
| 溶解度 | ≤0.25mg/ml in ethanol;25mg/ml in DMSO;50mg/ml in dimethyl formamide |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述：
4-methyl Erlotinib is an analog of erlotinib by the addition of a methyl group at the four position of the phenyl group. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR) [1].
The epidermal growth factor receptor (EGFR) autocrine pathway has been important for cancer development and progression, including cell proliferation, apoptosis, angiogenesis, and metastatic spread [2].
Erlotinib inhibits EGFR-associated kinase activity by binding to the EGF-activated receptor, with the phenyl group at one end sequestered in a hydrophobic pocket of the kinase domain and the ether linkages at the opposite end projecting into solvent [1].
Erlotinib can prolong survival in patients with non–small-cell lung cancer after first-line or second-line chemotherapy [3].
特别提醒：
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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