化学性质:
规格 | 10mM*1mLinDMSO 1mg 5mg |
CAS | 5041-67-8 |
别名 | N/A |
化学名 | N/A |
分子式 | C20H18O10 |
分子量 | 418.35 |
溶解度 | Methanol : 16.67 mg/mL (39.85 mM) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Juglanin is a JNK activator.
Juglanin inhibits the proliferation of breast cancer cell in a dose- and time-dependent manner and presents less cytotoxic against the normal cells. Juglanin results in the accumulation of cancer cells in G2/M phase and a corresponding decrease in G0/G1 and S phases in both MCF-7 and SKBR3 cells. Juglanin up-regulates the expressions of phosphorylated Chk2, Chk2, phosphorylated Cdc25C, phosphorylated Cdc2, p27, cyclin D and down-regulates the levels of Cdc25C as well as Cdc2. The proportion of apoptosis is negligible for control cells, whereas 24 h of exposure of cells to Juglanin leads to a dose-dependent increase of apoptotic cells in both MCF-7 and SKBR3 cells. Juglanin significantly suppresses anti-apoptotic factor of Bcl-2 expression, and in contrast Bad and Bax are both up-regulated for Juglanin treatment. Juglanin markedly activates caspases and leads to Casapse-9, Casapse-8 and Caspase-3 cleavage. ROS generation is initiated by Juglanin and significantly increased by high concentrations of Juglanin. Juglanin also increases the level of JNK phosphorylation in both MCF-7 and SKBR3 cells[1].
Juglanin at doses of 5 and 10 mg/kg leads to significant decrease in tumor volume after 7 days of drug administration. 5 and 10 mg/kg Juglanin treatments do not cause weight loss in mice[1].
[1]. Sun ZL, et al. Juglanin induces apoptosis and autophagy in human breast cancer progression via ROS/JNK promotion. Biomed Pharmacother. 2017 Jan;85:303-312.
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标签:Juglanin
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