化学性质:
规格 | 10mM (in 1mL DMSO) 10mg 25mg |
CAS | 1380432-32-5 |
别名 |
|
化学名 | 4-N-(9-ethylcarbazol-3-yl)-2-N-(3-morpholin-4-ylpropyl)pyrimidine-2,4-diamine |
分子式 | C25H30N6O |
分子量 | 430.55 |
溶解度 | ≥ 25.6mg/mL in DMSO with gentle warming |
储存条件 | Store at -20° C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
EHop-016 is a novel and specific inhibitor of Rac1 and Rac3 activity (IC50= 1.1 μm).
Rac is a member of the RAS superfamily of small GTPase. It functions in various cellular processes including regulation of secretory processes, membrane ruffles, cell polarization and phagocytosis of apoptotic cells etc. It is contributed to malignant progression.
Ehop-016 inhibited Rac activity in metastatic cancer cell MDA-MB-435 which overexpressed Rac and inhibited high endogenous Rac activity as well. In metastatic breast cancer cell MDA-MB-231, Ehop-016 blocked the Rac activity and reduced Rac-mediated lamelipodia formation. It also attenuated the effects of Rac downstream protein p21-activated kinase 1 and directed migration of metastatic cancer cells. [1]
In C3H/HeJ mice carrying KITD814V following overnight treatment of 2.5 μM EHop-016 or 25 μM NSC23766, EHop-016 reduced spleen size and PB counts thus significantly promoted the survival of leukemic mice compared with NSC23766. [2]格
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标签:EHop-016
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