化学性质:
规格 | 1mg 5mg |
CAS | 121569-61-7 |
别名 | 7-epi-hydroxy Staurosporine |
化学名 | (3S,9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one |
分子式 | C28H26N4O4 |
分子量 | 482.5 |
溶解度 | Ethanol: 1 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01, which has been first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite [1]. UCN-02 is protein kinase C inhibitor [1].
Protein kinase C (PKC), which can phosphorylate serine and threonine, is a family of protein kinase enzymes involved in regulating the function of other proteins. Protein kinase C plays an important role in several signal transduction cascades. Protein kinase C has been implicated in modulating membrane structure events, mediating immune responses, regulating transcription, learning and memory, and regulating cell growth [2].
UCN-02 inhibited protein kinase C with a slightly reduced potency than UCN-01. The IC50 values were 62 and 4.1 nM for UNC-02 and UCN-01, respectively. UCN-02 was cytotoxic to the growth of HeLa S3 cells.
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标签:UCN-02
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