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抑制剂 > 新陈代谢类 > N-Acetyl-4-benzoquinone imine
产品名称:
N-Acetyl-4-benzoquinone imine
型号:
CS-01Y69232
生产地址
进口、国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

500μg 1mg 5mg

CAS

50700-49-7

别名

N/A

化学名

N/A

分子式

C8H7NO2

分子量

149.2

溶解度

Chloroform: 1 mg/ml*,Chloroform/Ethyl Acetate (1:1): 1 mg/ml,Ether: 1 mg/ml,Ethyl Acetate: 1 mg/ml

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                            

N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:N-Acetyl-4-benzoquinone imine 

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