化学性质:
规格 | 1 mg 5 mg |
CAS | 17680-99-8 |
别名 | N/A |
化学名 | N/A |
分子式 | C13H16O7 |
分子量 | 284.3 |
溶解度 | Ethanol: soluble |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
p-Cresol glucuronide is a metabolite of p-cresol, a uremic toxin formed by bacterial fermentation of proteins in the large intestine.1 It is formed from p-cresol primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A6, but also by UGT1A9, in human liver and kidney microsomes. p-Cresol glucuronide accumulates in feces, blood, and urine of patients with chronic kidney disease (CKD).2
1.Rong, Y., and Kiang, T.K.L.Characterizations of human UDP-glucuronosyltransferase enzymes in the conjugation of p-cresolToxicol. Sci.176(2)285-296(2020) 2.Gryp, T., De Paepe, K., Vanholder, R., et al.Gut microbiota generation of protein-bound uremic toxins and related metabolites is not altered at different stages of chronic kidney diseaseKidney Int.97(6)1230-1242(2020)
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