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抑制剂 > 新陈代谢类 > Sildenafil
产品名称:
Sildenafil
型号:
CS-01Y69221
生产地址
进口、国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

10mM (in 1mL Water) 25mg 50mg 500mg

CAS

139755-83-2

别名

Revatio;UK-92480;Viagra

化学名

5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one

分子式

C22H30N6O4S

分子量

474.58

溶解度

46.3 mg/mL in DMSO with ultrasonic, 22.65 mg/mL in H2O

储存条件

Store at 4°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                            

Sildenafil is a selective inhibitor of phosphodiesterase-5 (PDE5) [1].

Phosphodiesterases (PDEs) are enzymes that hydrolyzing cyclic nucleotides cAMP and cGMP to their inactive 5'-monofosfatos forms. The PDE5 enzyme is responsible for the hydrolysis of the cGMP, which restores GMP levels [1].

In human umbilical vein endothelial cells (HUVECs), Sildenafil (1 mM/5 h) significantly enhanced NO production, which is ~1.5-fold higher than the effect achieved with insulin (100 nM/1 h) [2].

In male C57BL/6 mice, Sildenafil increased glandular activity of the prostate. The secretory epithelium lining showed tall columnar cells. Moreover, the glandular apical region showed evident secretion vesicles. Also, Sildenafil increased substantially testosterone serum levels [1]. In human corpora cavernosa, Sildenafil inhibited PDE5 with a mean IC50 of 3.9 nM. In 12 patients with erectile dysfunction, Sildenafil enhanced the erectile response, which suggested that PDE5 played an important role in human penile erection. So Sildenafil plays as a new effective treatment for penile erectile dysfunction [3].

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:Sildenafil 

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