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L-Leucine-d10 is intended for use as an internal standard for the quantification of L-leucine by GC- or LC-MS. L-Leucine is an essential amino acid.1 It increases basal insulin secretion and decreases glucose-induced insulin release in INS-1E rat insulinoma cells when used at concentrations of 1, 5, and 10 mM.2 L-Leucine (1, 5, and 10 mM) decreases triglyceride levels and increases cholesterol accumulation in INS-1E cells. It stimulates skeletal muscle protein synthesis in exercised rats, as well as in food-deprived rats in an mTOR-dependent manner.3,4 Formulations containing L-leucine have been used as dietary 

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