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L-Alanine-d3 is intended for use as an internal standard for the quantification of L-alanine by GC- or LC-MS. L-Alanine is a non-essential amino acid.1 It is produced by direct β-decarboxylation of L-aspartate by L-aspartate β-decarboxylase or transamination of pyruvate in the glucose-alanine cycle and is a precursor for gluconeogenesis.2 Dysregulation of L-alanine metabolism is associated with various disease states, including diabetes, metabolic syndrome, ketotic hypoglycemia, and acquired acute lactic acidosis.

1.Graber, R., Kasper, P., Malashkevich, V.N., et al.Conversion of aspartate aminotransferase into an L-aspartate β-decarboxylase by a triple active-site mutationJ. Biol. Chem.274(44)31203-31208(1999) 2.Felig, P.Progress in endocrinology and metabolism: The glucose-alanine cycleMetabolis.22(2)179-207(1973)

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