化学性质:
规格 | 500 μg 1 mg |
CAS | 1398065-69-4 |
别名 | N/A |
化学名 | N/A |
分子式 | C17H10Cl2D4F2N2O3 |
分子量 | 407.2 |
溶解度 | DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Roflumilast-d4 is intended for use as an internal standard for the quantification of roflumilast by GC- or LC-MS. Roflumilast is a potent, cell-permeable inhibitor of PDE4 (IC50 = <1 nM for both human PDE4B and PDE4D).1 It is selective for PDE4, with IC50 values against other PDE forms being greater than 10 μM.
1.Card, G.L., England, B.P., Suzuki, Y., et al.Structural basis for the activity of drugs that inhibit phosphodiesterasesStructure12(12)2233-2247(2004)
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