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Glycolithocholic acid-d4 is intended for use as an internal standard for the quantification of glycolithocholic acid by GC- or LC-MS. Glycolithocholic acid is a glycine-conjugated form of the secondary bile acid lithocholic acid .1 It is increased in the liver of mice fed a diet supplemented with ursodeoxycholic acid .2 Glycolithocholic acid levels are decreased in the plasma following subcutaneous administration of PEG-obestatin(Cys10, Cys13), a modified peptide hormone, in lean or diet-induced obese mice.3 Serum glycolithocholic acid levels increase with age in children.4

1.Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1)147-191(2009) 2.Zhang, Y., and Klaassen, C.D.Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in miceJ. Lipid Res.51(11)3230-3242(2010) 3.Cowan, E., Kimar, P., Burch, K.J., et al.Treatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC-MS metabolomicsMetabolomics12(124)(2016) 4.Semba, R.D., Gonzalez-Freier, M., Moaddel, R., et al.Environmental enteric dysfunction is associated with altered bile acid metabolismJ. Pediatr. Gastenterol. Nutr.64(4)536-540(2017)

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