化学性质：                                                                                                             

产品描述：                                                                                                            

Hydroflumethiazide-13C-d2 is intended for use as an internal standard for the quantification of hydroflumethiazide by GC- or LC-MS. Hydroflumethiazide is a thiazide diuretic and an inhibitor of carbonic anhydrase (CA).1 It is selective for CAII, CAVB, CAVII, CAIX, CAXII, and CAXIV (Kis = 0.24-0.31 μM) over CAI, CAIV, and CAVI (Kis = 2.8-8.3 μM), as well as CAIII, CAVA, and CAXIII (Kis = >10 μM). Formulations containing hydroflumethiazide have been used in the treatment of hypertension.

1.Temperini, C., Cecchi, A., Scozzafava, A., et al.Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adductBioorg. Med. Chem. Lett.18(8)2567-2573(2008)

特别提醒：