N-desmethyl OlanzapineCS-01Y69099_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	1mg 5mg 10mg 25mg
CAS	161696-76-0
别名	N/A
化学名	N/A
分子式	C16H18N4S
分子量	298.4
溶解度	DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 10 mg/ml
储存条件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

N-desmethyl Olanzapine is a major metabolite of the atypical antipsychotic agent olanzapine .1,2 N-desmethyl Olanzapine is formed via oxidative metabolism of olanzapine by the cytochrome 450 (CYP) isoform CYP1A2.1

1.Ring, B.J., Catlow, J., Lindsay, T.J., et al.Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapineJ. Pharmacol. Exp. Ther.276(2)658-666(1996) 2.Chiu, J.A., and Franklin, R.B.Analysis and pharmacokinetics of olanzapine (LY170053) and two metabolites in rat plasma using reversed-phase HPLC with electrochemical detectionJ. Pharm. Biomed. Anal.14(5)609-615(1996)

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标签：N-desmethyl Olanzapine

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