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N-acetyl-L-Cysteine ethyl ester is an esterified form of N-acetyl-L-cysteine . It has enhanced cell permeability in isolated perfused rat liver compared to NAC.1 N-acetyl-L-Cysteine ethyl ester (1 mM) prevents tert-butyl hydroperoxide-induced formation of methemoglobin in isolated human red blood cells. It increases glutathione levels in rat liver, kidney, heart, testis, and brain when administered at a dose of 50 mg/kg twice per day for two weeks. N-acetyl-L-Cysteine ethyl ester reduces increases in plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels induced by paracetamol in rats.

1.Giustarini, D., Milzani, A., Dalle-Donne, I., et al.N-Acetylcysteine ethyl ester (NACET): A novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potentialBiochem. Pharmacol.84(11)1522-1533(2012)

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