化学性质:
规格 | 1 mg 5 mg 10 mg |
CAS | 566-17-6 |
别名 | isoDCA |
化学名 | (5β,7α,12α)-7,12-dihydroxy-cholan-24-oic acid |
分子式 | C24H40O4 |
分子量 | 392.6 |
溶解度 | DMF: 30mg/mL,DMF:PBS (pH 7.2) (1:1): 0.5mg/mL,DMSO: 20mg/mL,Ethanol: 20mg/mL |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Isodeoxycholic acid is a bile acid that is formed via epimerization of deoxycholic acid by intestinal bacteria.[1] It has a greater critical micelle concentration than DCA, indicating reduced detergent activity, and is less active than DCA in inhibiting growth in a panel of seven gut commensal bacteria species. Isodeoxycholic acid (0.1%) inhibits spore germination induced by taurocholic acid in several C. difficile strains, as well as decreases the cytotoxicity of C. difficile culture supernatants to Vero cells.[2] Plasma levels of isodeoxycholic acid are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.[3]
特别提醒:
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